Biographic Sketch

 

 Daniel Wall, Ph.D.

                                                                                                  

Education

 

1998                Postdoctoral Fellow, Departments of Biochemistry & Developmental Biology, Stanford University, Stanford, CA.

1994                Ph.D., Molecular Microbiology, University of Utah, Salt Lake City, UT.

1988                B.A., Biology, Sonoma State University, Rohnert Park, CA.

                                               

Professional Experience

 

2007-present    Assistant Professor, Department of Molecular Biology, University of Wyoming, Laramie, WY.

2005-present    NIH reviewer: Infectious Disease Microbiology H(10); a.k.a. “Bugs and Drugs” panel.

2007                Instructor, Biology Department, Grossmont College, El Cajon, CA.

2002- 2006      Principal Scientist, Head of Microbiology & Antibiotic Drug Discovery, Anadys Pharmaceuticals, San Diego, CA. 

2001–2002      Senior Scientist, Elitra Pharmaceuticals, San Diego, CA.

1999-2001       Scientist II, Elitra Pharmaceuticals, San Diego, CA.                  

1988-1989       Research Associate, Department of Biology, Sonoma State University, Rohnert Park, CA.  

 

Publications

1.      Wall, D., Delaney, J., Fayet, O., Lipinska, B., Yamamoto, T. and Georgopoulos, C. 1992. arc-Dependent thermal regulation and extragenic suppression of the E. coli cytochrome d operon. J. Bacteriol. 174, 6554-6562.

 

2.      Georgopoulos, C., Wall, D., Wu, B., Vouganis, D. and Raina, S. 1992. Function and regulation of the universally conserved heat-shock response. In Radiation Research: a twentieth-century perspective. (Dewey, W. C., Edington, M., Fry, R. J. M., Hall, E. J. & Whitmore, G. F., eds), pp. 962-969, Academic Press, Inc., San Diego, CA.

 

3.      Delaney, J., Wall, D. and Georgopoulos, C. 1993. Molecular characterization of the Escherichia coli htrD gene: cloning, regulation and involvement with cytochrome d oxidase. J. Bacteriol. 175:166-175.

 

4.      Wall, D., Zylicz, M. and Georgopoulos, C. 1994. The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for l replication.  J. Biol. Chem. 269:5446-5451.

 

5.      Szyperski, T., Pellecchia, M., Wall, D., Georgopoulos, C., and Wuthrich, K. 1994. NMR structure determination of the Escherichia coli DnaJ molecular chaperone. Proc. Natl. Acad. Sci. USA. 91:11343-11347.

 

6.      Wall, D. 1994. Structure-function studies of the Escherichia coli DnaJ molecular    chaperone. Ph.D. dissertation, University of Utah.

 

7.      Wall, D., Zylicz, M. and Georgopoulos, C. 1995. The conserved G/F motif of the DnaJ chaperone is necessary for the activation of the substrate binding properties of the DnaK chaperone. J. Biol. Chem. 270:2139-2144.

 

8.      Liberek, K., Wall, D., and Georgopoulos, C. 1995. The DnaJ chaperone catalytically activates the DnaK chaperone to preferentially bind the s 32 heat shock transcription regulator. Proc. Natl. Acad. Sci. USA. 92:6224-6228.

 

9.      Wawrzynow, A., Banecki, B., Wall, D., Liberek, K., Georgopoulos, C. and Zylicz, M. 1995. ATP hydrolysis is required for the DnaJ-dependent activation of the DnaK chaperone for binding to both native and denatured protein substrates. J. Biol. Chem. 270:19307-19311.

 

10.  Banecki, B., Liberek, K., Wall, D., Wawrzynow, A., Georgopoulos, C., Bertoli, E., Tanfani, F. and Zylicz, M. 1996. Structure-function analysis of the zinc finger region of the DnaJ molecular chaperone. J. Biol. Chem. 271:14840-14848.

 

11.  Pellecchia, M., Szyperski, T., Wall, D., Georgopoulos, C. and Wuthrich, K. 1996. NMR structure of the J-domain and the gly/phe-rich region of the Escherichia coli DnaJ chaperone. J. Mol. Biol. 260:236-250.

 

12.  Wall, D., Wu, S. and Kaiser, D. 1998. Contact stimulation of Tgl and Type IV pili in Myxococcus xanthus. J. Bacteriol. 180:759-761.

 

13.  Wall, D., and Kaiser, D. 1998. Alignment enhances the cell-to-cell transfer of pilus phenotype. Proc. Natl. Acad. Sci. USA. 95:3054-3058.

 

14.  Wall, D., Kolenbrander, P.E. and Kaiser, D. 1999. Myxococcus xanthus pilQ (sglA) gene encodes a secretin homolog required for type IV pili biogenesis, S motility and development.  J. Bacteriol. 181: 24-33.

 

15.  Wall, D. and Kaiser, D. 1999. Type IV pili and cell motility. Mol. Microbiol. 32:1-10. Review.

 

16.  Forsyth, R. A., Haselbeck, R. J., Ohlsen, K. L., Yamamoto, R. T., Xu, H., Trawick, J. D., Wall, D., Wang, L., Brown-Driver, V., Froelich, J. M., Kedar, G. C., King, P., McCarthy, M., Malone, C., Misiner, B., Robbins, D., Tan, Z., Zhu, Z., Carr, G., Mosca, D. A., Zamudio, C., Foulkes, J. D. and Zyskind, J. W. 2002. A Genome-Wide Strategy for the Identification of the Essential Genes in Staphylococcus aureus. Mol. Microbiol. 43:1387-1400.

 

17.  Haselbeck, R., Wall, D., Jiang, B., Ketela, T., Zyskind, J., Bussey, H., Foulkes, J.G. and Roemer, T. 2002. Comprehensive essential gene identification as a platform for novel antibiotic drug discovery. Current Pharmaceutical Design. 8:1155-1172.

 

18.  Han, Q., Zhao, Q., Fish, S., Simonsen, K.B., Vourloumis, D., Froelich, J., Wall, D. Hermann, T. 2005. Molecular recognition by glycoside pseudo-base pairs and triples in an apramycin-RNA complex. Angewandte Chemie. 44:2694-2700.

 

19.  Nudleman, E., Wall, D. and Kaiser, D. 2005. Cell-to-cell transfer of bacterial outer membrane proteins. Science 309:125-127.

 

20.  Zhou, Y., Gregor, V. E., Sun, Z., Ayida, B. K., Winters, G. C., Murphy D., Simonsen, K. B., Vourloumis, D., Fish, S., Froelich J.M., Wall, D. and Hermann, T. 2005. Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors. Antimicrob. Agents Chemother. 49:4942-4949.

 

21.  Froelich, J. M., Khoa, T., and Wall, D. 2006. A pmrA constitutive mutant sensitizes Escherichia coli to deoxycholic acid. J. Bacteriol. 188:1180-1183.

 

22.  Nudleman, E., Wall, D. and Kaiser, D. 2006. Polar assembly of the type IV pilus secretin in Myxococcus xanthus. Mol. Microbiol. 60:16-29.

 

23.  Zhou, Y., Sun, Z., Froelich, J. M., Hermann, T. and Wall, D. 2006. Structure-activity relationships of novel antibacterial translation inhibitors: 3,5-diamino-piperidinyl triazines. Bioorg. Med. Chem. Lett. 16:5451-5456.

 

24.  Zhou, Y., Gregor, V., Ayida, B., Winters, G. C., Sun, Z., Murphy, D., Haley, G., Bailey, D., Froelich, J. M., Fish, S., Webber, S. E., Hermann, T. and Wall, D. 2007. Synthesis and SAR of 3,5-diamino-piperidine derivatives: Novel antibacterial translation inhibitors as aminoglycoside mimetics. Bioorg. Med. Chem. Lett. 17:1206-1210.

 

25.  Zhou, Y., Bertolini, T., Sun, Z., Murphy, D., Froelich, J. M., Webber, S. E., Hermann, T. and Wall, D. SAR of serum and antibacterial activity of the 3,5-diamino-piperidine translation inhibitors. In prep.

 

Patents

 

Haselbeck, R., Ohlsen, K. L., Zyskind, J. W., Wall, D., Trawick, J. D., Carr, G. J., Yamamoto, R. T., Xu, H. H. Identification of essential genes in prokaryotes. September 2001. PCT WO 01/70955 A2

 

Haselbeck, R., Wall, D., Gross, M. Bacterial promoters and methods of use. July 2002. PCT WO 02/51982 A2

 

Wang, L., Zamudio, C., Malone, C., Haselbeck, R., Ohlsen, K. L., Zyskind, J. W., Wall, D., Trawick, J. D., Carr, G. J., Yamamoto, R., Forsyth, R. A., Xu, H. H., Identification of essential genes in microorganisms. October 2002. PCT WO 02/77183 A2

 

Carr, G. J., Xu, H. H., Foulkes, G. J., Zamudio, C., Haselbeck, R., Ohlsen, K. L., Zyskind, J. W., Wall, D., Trawick, J. D. Yamamoto, R. T., Roemer, T., Jiang, B. Boone, C., Bussey, H.  Methods for identifying the target of a compound, which inhibits cellular proliferation. October 2002. PCT WO 02/86097 A2

 

Wall, D. and J. Froelich. Stabilized nucleic acids in gene and drug discovery and methods of use. Appl. No.: 10/327,592